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Chronic Treatment with Escitalopram but Not R-Citalopram Translocates Gα(s) from Lipid Raft Domains and Potentiates Adenylyl Cyclase: A 5-Hydroxytryptamine Transporter-Independent Action of This Antidepressant Compound
Chronic antidepressant treatment has been shown to increase adenylyl cyclase activity, in part, due to translocation of Gα(s) from lipid rafts to a nonraft fraction of the plasma membrane where they engage in a more facile stimulation of adenylyl cyclase. This effect holds for multiple classes of an...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835448/ https://ncbi.nlm.nih.gov/pubmed/19996298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162644 |
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