Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C(1) and A(1)

Disorazoles are macrocyclic polyketides first isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. Both the major fermentation product disorazole A(1) and its much rarer companion disorazole C(1) exhibit potent cytotoxic activity against many human tumor cells. Furthermore...

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Detalhes bibliográficos
Main Authors: Lazo, John S., Reese, Celeste E., Vogt, Andreas, Vollmer, Laura L., Kitchens, Carolyn A., Günther, Eckhard, Graham, Thomas H., Hopkins, Chad D., Wipf, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835430/
https://ncbi.nlm.nih.gov/pubmed/20008956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162842
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