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A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment

The retinoic acid (RA) signal, produced locally from vitamin A by retinaldehyde dehydrogenase (Raldh) and transduced by the nuclear receptors for retinoids (RA receptor and 9-cis-RA receptor), is indispensable for ontogenesis and homeostasis of numerous tissues. We demonstrate that Raldh3 knockout i...

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Main Authors: Dupé, Valérie, Matt, Nicolas, Garnier, Jean-Marie, Chambon, Pierre, Mark, Manuel, Ghyselinck, Norbert B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC283541/
https://ncbi.nlm.nih.gov/pubmed/14623956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2336223100
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