Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma

Rexin-G, a pathotropic nanoparticle bearing a cytocidal cyclin G1 construct was tested in a phase I/II study for chemotherapy-resistant sarcomas and a phase II study for chemotherapy-resistant osteosarcoma. Twenty sarcoma patients and 22 osteosarcoma patients received escalating doses of Rexin-G int...

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Detalhes bibliográficos
Main Authors: Chawla, Sant P, Chua, Victoria S, Fernandez, Lita, Quon, Doris, Saralou, Andreh, Blackwelder, William C, Hall, Frederick L, Gordon, Erlinda M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835268/
https://ncbi.nlm.nih.gov/pubmed/19532136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.126
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