Physiological Transgene Regulation and Functional Complementation of a Neurological Disease Gene Deficiency in Neurons

The microtubule-associated protein tau (MAPT) and α-synuclein (SNCA) genes play central roles in neurodegenerative disorders. Mutations in each gene cause familial disease, whereas common genetic variation at both loci contributes to susceptibility to sporadic neurodegenerative disease. Here, we dem...

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Detalhes bibliográficos
Main Authors: Peruzzi, Pier Paolo, Lawler, Sean E, Senior, Steve L, Dmitrieva, Nina, Edser, Pauline AH, Gianni, Davide, Chiocca, E Antonio, Wade-Martins, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835262/
https://ncbi.nlm.nih.gov/pubmed/19352323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.64
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