Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis

The promoter regions of genes that are differentially regulated in the synovial membrane during the course of rheumatoid arthritis (RA) represent attractive candidates for application in transcriptionally targeted gene therapy. In this study, we applied an unbiased computational approach to define p...

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Autores principales: Geurts, Jeroen, Joosten, Leo AB, Takahashi, Nozomi, Arntz, Onno J, Glück, Anton, Bennink, Miranda B, van den Berg, Wim B, van de Loo, Fons AJ
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835043/
https://ncbi.nlm.nih.gov/pubmed/19690516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.182
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