Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this...

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Autori principali: Robey, Ian F., Baggett, Brenda K., Kirkpatrick, Nathaniel D., Roe, Denise J., Dosescu, Julie, Sloane, Bonnie F., Hashim, Arig Ibrahim, Morse, David L., Raghunand, Natarajan, Gatenby, Robert A., Gillies, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834485/
https://ncbi.nlm.nih.gov/pubmed/19276390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5575
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