Hypoxia Inducible Factor 1α Signaling in Fractionated Radiation-Induced Lung Injury: Role of Oxidative Stress and Tissue Hypoxia

To investigate the relationship of HIF1α signaling to oxidative stress, tissue hypoxia, angiogenesis and inflammation, female Fischer 344 rats were irradiated to the right hemithorax with a fractionated dose of 40 Gy (8 Gy × 5 days). The lung tissues were harvested before and at 4, 6, 10, 14, 18, 22...

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Main Authors: Rabbani, Z. N., Mi, J., Zhang, Y., Delong, M., Jackson, I. L., Fleckenstein, K., Salahuddin, F. K., Zhang, X., Clary, B., Anscher, M. S., Vujaskovic, Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834297/
https://ncbi.nlm.nih.gov/pubmed/20095848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1816.1
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