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Gas Phase Bio-conjugation of Peptides via Ion/Ion Charge Inversion: Schiff Base Formation on the Conversion of Cations to Anions

The selective covalent modification of singly protonated peptides in the gas-phase via ion/ion charge inversion reactions is demonstrated. Doubly deprotonated 4-formyl-1,3-benzene disulfonic acid serves as a reagent anion for forming a Schiff base via the reaction of a primary amine on the peptide a...

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Bibliografiske detaljer
Main Authors: Hassell, Kerry M., Stutzman, John R., McLuckey, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834292/
https://ncbi.nlm.nih.gov/pubmed/20121142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac902732v
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