The C-terminus of cardiac troponin I stabilizes the Ca(2+)-activated state of tropomyosin on actin filaments

RATIONALE: Ca(2+) control of troponin-tropomyosin position on actin regulates cardiac muscle contraction. The inhibitory subunit of troponin, cardiac troponin I (cTnI) is primarily responsible for maintaining a tropomyosin conformation that prevents crossbridge cycling. Despite extensive characteriz...

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Main Authors: Galińska, Agnieszka, Hatch, Victoria, Craig, Roger, Murphy, Anne M., Van Eyk, Jennifer E., Wang, C.-L. Albert, Lehman, William, Foster, D. Brian
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834238/
https://ncbi.nlm.nih.gov/pubmed/20035081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.210047
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