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Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting

In a subset of patients with the hereditary kidney-stone disease primary hyperoxaluria type 1 (PH1), the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria. This is a consequence of the combined presence of the common P11L polymorphism and...

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Hlavní autoři: Djordjevic, Snezana, Zhang, Xiaoxuan, Bartlam, Mark, Ye, Sheng, Rao, Zihe, Danpure, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833026/
https://ncbi.nlm.nih.gov/pubmed/20208150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109054645
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