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Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088
CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab fragment revealed an unusual noncanonical conformation of CDR L1. Most antibodies with the κ light chain exhibit a canonical structure for CDR L1 in which residue 29 anchors the CDR loop to the framework. Analysis of th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2833025/ https://ncbi.nlm.nih.gov/pubmed/20208149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109054141 |
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