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Symplocamide A, a Potent Cytotoxin and Chymotrypsin Inhibitor from the Marine Cyanobacterium Symploca sp

Investigation of a Symploca sp. from Papua New Guinea has led to the isolation of symplocamide A (1), a potent cancer cell cytotoxin, which also inhibits serine proteases with a 200-fold greater inhibition of chymotrypsin over trypsin. The complete stereostructure of symplocamide A was determined by...

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Detalhes bibliográficos
Main Authors: Linington, Roger G., Edwards, Daniel J., Shuman, Cynthia F., McPhail, Kerry L., Matainaho, Teatulohi, Gerwick, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832912/
https://ncbi.nlm.nih.gov/pubmed/18163584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np070280x
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