Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

The EphA4 tyrosine kinase cell surface receptor regulates an array of physiological processes and is the only currently known class A Eph receptor that binds both A and B class ephrins with high affinity. We have solved the crystal structure of the EphA4 ligand binding domain alone and in complex wi...

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Bibliografiske detaljer
Main Authors: Bowden, Thomas A., Aricescu, A. Radu, Nettleship, Joanne E., Siebold, Christian, Rahman-Huq, Nahid, Owens, Raymond J., Stuart, David I., Jones, E. Yvonne
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832735/
https://ncbi.nlm.nih.gov/pubmed/19836338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.07.018
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