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Mechanism of T-cell tolerance induced by myeloid-derived suppressor cells

Antigen-specific T-cell tolerance plays a critical role in tumor escape. Recent studies implicated myeloid-derived suppressor cells (MDSC) in the induction of CD8(+) T-cell tolerance in tumor-bearing hosts. However, the mechanism of this phenomenon remained unclear. We have found that incubation of...

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Detalhes bibliográficos
Main Authors: Nagaraj, Srinivas, Schrum, Adam G., Cho, Hyun-Il, Celis, Esteban, Gabrilovich, Dmitry I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832724/
https://ncbi.nlm.nih.gov/pubmed/20142361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902661
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