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Diversity of protein structures and difficulties in fold recognition: the curious case of protein G

We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for...

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Detalhes bibliográficos
Main Authors: Horst, Jeremy, Samudrala, Ram
Formato: Artigo
Idioma:Inglês
Publicado em: Biology Reports Ltd 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832337/
https://ncbi.nlm.nih.gov/pubmed/20209018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3410/B1-69
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