Improving the yeast two-hybrid system with permutated fusions proteins: the Varicella Zoster Virus interactome

BACKGROUND: Yeast two-hybrid (Y2H) screens have been among the most powerful methods to detect and analyze protein-protein interactions. However, they suffer from a significant degree of false negatives, i.e. true interactions that are not detected, and to a certain degree from false positives, i.e....

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Bibliografiske detaljer
Main Authors: Stellberger, Thorsten, Häuser, Roman, Baiker, Armin, Pothineni, Venkata R, Haas, Jürgen, Uetz, Peter
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832230/
https://ncbi.nlm.nih.gov/pubmed/20205919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-8-8
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