Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice: The Role of Tumor Necrosis Factor α

Inflammation may play a role in the etiology of both degenerative and rheumatic cardiac valve diseases. We report here that mice deficient in tristetraprolin (TTP), a protein with known anti-inflammatory functions, develop severe left-sided cardiac valvulitis. TTP is an mRNA binding protein that inh...

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Bibliographic Details
Main Authors: Ghosh, Sanjukta, Hoenerhoff, Mark J., Clayton, Natasha, Myers, Page, Stumpo, Deborah J., Maronpot, Robert R., Blackshear, Perry J.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832167/
https://ncbi.nlm.nih.gov/pubmed/20093488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090498
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