Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

Severe pulmonary hypertension is irreversible and often fatal. Abnormal proliferation and resistance to apoptosis of endothelial cells (ECs) and hypertrophy of smooth muscle cells in this disease are linked to decreased mitochondria and preferential energy generation by glycolysis. We hypothesized t...

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Detalhes bibliográficos
Main Authors: Fijalkowska, Iwona, Xu, Weiling, Comhair, Suzy A.A., Janocha, Allison J., Mavrakis, Lori A., Krishnamachary, Balaji, Zhen, Lijie, Mao, Thianzi, Richter, Amy, Erzurum, Serpil C., Tuder, Rubin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832136/
https://ncbi.nlm.nih.gov/pubmed/20110409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090832
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