Ca(2+) influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells

Ca(2+) signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] and diacylglycerol (DAG) controls lymphocyte activation. In contrast to store-operated Ca(2+) entry activated by Ins(1,4,5)P(3)-induced Ca(2+) release from endoplasmic reticulum, the importance o...

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Main Authors: Numaga, Takuro, Nishida, Motohiro, Kiyonaka, Shigeki, Kato, Kenta, Katano, Masahiro, Mori, Emiko, Kurosaki, Tomohiro, Inoue, Ryuji, Hikida, Masaki, Putney, James W., Mori, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2010
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831761/
https://ncbi.nlm.nih.gov/pubmed/20179100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.061051
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