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Silencing of the methionine sulfoxide reductase A gene results in loss of mitochondrial membrane potential and increased ROS production in human lens cells

Accumulation of methionine sulfoxide (Met(O)) is a significant feature of human cataract and previous studies have shown that methionine sulfoxide reductase A (MsrA), which acts to repair Met(O), can defend human lens cells against oxidative stress induced cell death. A key feature of oxidative stre...

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Detalhes bibliográficos
Main Authors: Marchetti, Maria A., Lee, Wanda, Cowell, Tracy L., Wells, Tracy M., Weissbach, Herbert, Kantorow, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831415/
https://ncbi.nlm.nih.gov/pubmed/16934804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2006.07.005
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