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Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis
The nuclear poly(A)-binding protein 1 (PABPN1) is a ubiquitously expressed protein that plays a critical role in polyadenylation. Short expansions of the polyalanine tract in the N-terminus of PABPN1 lead to oculopharyngeal muscular dystrophy (OPMD), which is an adult onset disease characterized by...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830829/ https://ncbi.nlm.nih.gov/pubmed/20035013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp569 |
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