Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis

The nuclear poly(A)-binding protein 1 (PABPN1) is a ubiquitously expressed protein that plays a critical role in polyadenylation. Short expansions of the polyalanine tract in the N-terminus of PABPN1 lead to oculopharyngeal muscular dystrophy (OPMD), which is an adult onset disease characterized by...

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Main Authors: Apponi, Luciano H., Leung, Sara W., Williams, Kathryn R., Valentini, Sandro R., Corbett, Anita H., Pavlath, Grace K.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830829/
https://ncbi.nlm.nih.gov/pubmed/20035013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp569
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