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Intracellular Delivery of a Membrane-Impermeable Enzyme in Active Form using Functionalized Gold Nanoparticles

Gold nanoparticles were coated with a short peptide to promote intracellular delivery of membrane-impermeable proteins. Through microscopy and enzyme assays we demonstrated the particles were able to transport functional enzymes into variety of cell lines. Significantly, the transported proteins wer...

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Detalhes bibliográficos
Main Authors: Ghosh, Partha, Yang, Xiaochao, Arvizo, Rochelle, Zhu, Zheng-Jiang, Agasti, Sarit S., Mo, Zhihong, Rotello, Vincent M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830715/
https://ncbi.nlm.nih.gov/pubmed/20131834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907887z
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