Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells

Activation of zymogens within the pancreatic acinar cell is an early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause zymogen activation and pancreatitis. The effects of the CCK analog, caerulein, and alcohol on trypsin and chymotrypsin activation in is...

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Bibliographic Details
Main Authors: LU, ZHAO, KARNE, SURESH, KOLODECIK, THOMAS, GORELICK, FRED S.
Format: Artigo
Language:Inglês
Published: 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830557/
https://ncbi.nlm.nih.gov/pubmed/11842000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00388.2001
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