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Temperature-sensitive mutant in the vaccinia virus E6 protein produce virions that are transcriptionally inactive
The vaccinia virus E6R gene encodes a late protein that is packaged into virion cores. A temperature sensitive mutant was used to study the role of this protein in viral replicative cycle. Cts52 has a P226L missense mutation in the E6R gene, shows a two-log reduction in plaque formation, but display...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830351/ https://ncbi.nlm.nih.gov/pubmed/20116822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.01.010 |
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