TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

BACKGROUND: Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis. Pyk2 is a non-receptor tyrosine kinase and integrates signals in cell invasion. Howev...

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Detalhes bibliográficos
Main Authors: Zhang, Siyang, Guo, Dawei, Luo, Wenting, Zhang, Qingfu, Zhang, Ying, Li, Chunyan, Lu, Yao, Cui, Zeshi, Qiu, Xueshan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830183/
https://ncbi.nlm.nih.gov/pubmed/20156366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-43
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