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Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Activity in Normal, Mutant, and Heterozygote-Cultured Human Skin Fibroblasts

Cultured skin fibroblasts from patients deficient for the enzyme hypoxanthine-guanine phosphoribosyltransferase (PRT) activity show very low but nevertheless significant levels of apparent PRT enzyme despite absence of detectable activity (<0.004% of normal) in erythrocytes of the same patients....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fujimoto, Wilfred Y., Seegmiller, J. Edwin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1970
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC282946/
https://ncbi.nlm.nih.gov/pubmed/5267139
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