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Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer
Gene therapy for hemophilia B has been shown to result in long-term expression and immune tolerance to factor IX (F.IX) after in vivo transduction of hepatocytes with adeno-associated viral (AAV-2) vectors in experimental animals. An optimized protocol was effective in several strains of mice with a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Mary Ann Liebert, Inc.
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829279/ https://ncbi.nlm.nih.gov/pubmed/19309290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.161 |
| Oznake: |
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