Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer

Gene therapy for hemophilia B has been shown to result in long-term expression and immune tolerance to factor IX (F.IX) after in vivo transduction of hepatocytes with adeno-associated viral (AAV-2) vectors in experimental animals. An optimized protocol was effective in several strains of mice with a...

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Detalhes bibliográficos
Main Authors: Cooper, Mario, Nayak, Sushrusha, Hoffman, Brad E., Terhorst, Cox, Cao, Ou, Herzog, Roland W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Scientific Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829279/
https://ncbi.nlm.nih.gov/pubmed/19309290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.161
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