Adenosine A1 receptor, a target and regulator of ERα action, mediates the proliferative effects of estradiol in breast cancer

Estrogen receptor-α (ERα) and its ligand estradiol (E2) play critical roles in breast cancer growth and are key therapeutic targets. Here, we report a novel dual role of the adenosine A1 receptor (Adora1) as an E2/ERα target and a regulator of ERα transcriptional activity. In ERα-positive breast can...

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Detalhes bibliográficos
Main Authors: Lin, Zhihong, Yin, Ping, Reierstad, Scott, O’Halloran, Meghan, Coon V, John S., Pearson, Elizabeth K., Mutlu, Gökhan M., Bulun, Serdar E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829108/
https://ncbi.nlm.nih.gov/pubmed/19935720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.409
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