Vaccinia Protein F12 Has Structural Similarity to Kinesin Light Chain and Contains a Motor Binding Motif Required for Virion Export

Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds cargo. F12 and KLC share similar size, pI, hydr...

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Autors principals: Morgan, Gareth W., Hollinshead, Michael, Ferguson, Brian J., Murphy, Brendan J., Carpentier, David C. J., Smith, Geoffrey L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829069/
https://ncbi.nlm.nih.gov/pubmed/20195521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000785
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