Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke

BACKGROUND: The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor to early BBB dysfunctio...

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Détails bibliographiques
Auteurs principaux: Jin, Albert Y, Tuor, Ursula I, Rushforth, David, Kaur, Jaspreet, Muller, Robert N, Petterson, Jodie Lee, Boutry, Sébastien, Barber, Philip A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829030/
https://ncbi.nlm.nih.gov/pubmed/20122276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-12
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