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AMP579 is revealed to be a potent A(2b)-adenosine receptor agonist in human 293 cells and rabbit hearts

The mixed A(1)/A(2a)-adenosine agonist AMP579 given at reperfusion is protective in animal models of myocardial infarction. Receptor-blocking studies have indicated that the protection came from an adenosine receptor (AR), but neither A(1)- nor A(2a)-selective agonists could duplicate its protection...

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Autores principales: Liu, Yanping, Yang, Xiulan, Yang, Xi-Ming, Walker, Sheree, Förster, Karina, Cohen, Michael V., Krieg, Thomas, Downey, James M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828901/
https://ncbi.nlm.nih.gov/pubmed/19730798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-009-0056-9
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