Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

OBJECTIVE: High concentrations of circulating glucose are believed to contribute to defective insulin secretion and β-cell function in diabetes and at least some of this effect appears to be caused by glucose-induced β-cell apoptosis. In mammalian cells, apoptotic cell death is controlled by the int...

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Autori principali: McKenzie, Mark D., Jamieson, Emma, Jansen, Elisa S., Scott, Clare L., Huang, David C.S., Bouillet, Philippe, Allison, Janette, Kay, Thomas W.H., Strasser, Andreas, Thomas, Helen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828664/
https://ncbi.nlm.nih.gov/pubmed/19959756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1151
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