Palmitic Acid Is a Novel CD4 Fusion Inhibitor That Blocks HIV Entry and Infection

The high rate of HIV-1 mutation and the frequent sexual transmission highlight the need for novel therapeutic modalities with broad activity against both CXCR4 (X4) and CCR5 (R5)-tropic viruses. We investigated a large number of natural products, and from Sargassum fusiforme we isolated and identifi...

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Bibliografiske detaljer
Main Authors: Lee, David Y.-W., Lin, Xudong, Paskaleva, Elena E., Liu, Yanze, Puttamadappa, Shadakshara S., Thornber, Carol, Drake, James R., Habulin, Maja, Shekhtman, Alexander, Canki, Mario
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2009
Fag:
Preclinical Studies/Drug Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828184/
https://ncbi.nlm.nih.gov/pubmed/20001317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2009.0019
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