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Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells

Cerebellar granule (CG) cells generate high-frequency action potentials that have been proposed to depend on the unique properties of their voltage-gated ion channels. To address the in vivo function of Nav1.6 channels in developing and mature CG cells, we combined the study of the developmental exp...

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Autori principali: Osorio, Nancy, Cathala, Laurence, Meisler, Miriam H, Crest, Marcel, Magistretti, Jacopo, Delmas, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828138/
https://ncbi.nlm.nih.gov/pubmed/20173079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.183798
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