The mixed-lineage kinase 1–3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors

BACKGROUND AND PURPOSE: The mixed-lineage kinases (MLKs) act upstream of mitogen-activated protein kinases, but their role in cardiac biology and pathology is largely unknown. EXPERIMENTAL APPROACH: We investigated the effect of a MLK1–3 inhibitor CEP-11004 on G protein-coupled receptor agonist-indu...

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Hlavní autoři: Ola, A, Kerkelä, R, Tokola, H, Pikkarainen, S, Skoumal, R, Vuolteenaho, O, Ruskoaho, H
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2010
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828035/
https://ncbi.nlm.nih.gov/pubmed/20067472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00567.x
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