The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice

BACKGROUND AND PURPOSE: Recent findings suggest the importance of mast cells in the pathogenesis of rheumatoid arthritis and their potential as a therapeutic target. Tranilast is an anti-allergic compound with a potent membrane-stabilizing effect on mast cells and a wide range of anti-inflammatory e...

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Autors principals: Shiota, N, Kovanen, PT, Eklund, KK, Shibata, N, Shimoura, K, Niibayashi, T, Shimbori, C, Okunishi, H
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828026/
https://ncbi.nlm.nih.gov/pubmed/20067475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00561.x
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