Targeting the Degradation of Angiotensin II with Recombinant ACE2: Prevention of Angiotensin II-dependent Hypertension

Angiotensin converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) to form Ang-(1-7). Here we examined whether soluble human recombinant ACE2 (rACE2) can efficiently lower Ang II and increase Ang-(1-7), and whether rACE2 can prevent hypertension caused by Ang II infusion as a result of systemic...

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Bibliografische gegevens
Hoofdauteurs: Wysocki, Jan, Ye, Minghao, Rodriguez, Eva, González-Pacheco, Francisco R., Barrios, Clara, Evora, Karla, Schuster, Manfred, Loibner, Hans, Brosnihan, K. Bridget, Ferrario, Carlos M., Penninger, Josef M., Batlle, Daniel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827767/
https://ncbi.nlm.nih.gov/pubmed/19948988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.138420
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