Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation

Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel. We now demonstrate that retinoic acid (RA) is crucial for GDNF-induced ENS precursor migration, cell polarization and lamellipodia formation,...

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Main Authors: Fu, Ming, Sato, Yoshiharu, Lyons-Warren, Ariel, Zhang, Bin, Kane, Maureen A., Napoli, Joseph L., Heuckeroth, Robert O.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827616/
https://ncbi.nlm.nih.gov/pubmed/20110328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.040550
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