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Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel. We now demonstrate that retinoic acid (RA) is crucial for GDNF-induced ENS precursor migration, cell polarization and lamellipodia formation,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2827616/ https://ncbi.nlm.nih.gov/pubmed/20110328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.040550 |
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