α(1A)-Adrenergic Receptor-Directed Autoimmunity Induces Left Ventricular Damage and Diastolic Dysfunction in Rats

BACKGROUND: Agonistic autoantibodies to the α(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is uncertain. METHODS/PRINCIPAL FINDINGS: We immunized Lewis rats with the second extracellular-loop peptides of the human α(1A)-adrenergic rec...

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Main Authors: Wenzel, Katrin, Wallukat, Gerd, Qadri, Fatimunnisa, Hubner, Norbert, Schulz, Herbert, Hummel, Oliver, Herse, Florian, Heuser, Arnd, Fischer, Robert, Heidecke, Harald, Luft, Friedrich C., Muller, Dominik N., Dietz, Rainer, Dechend, Ralf
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827566/
https://ncbi.nlm.nih.gov/pubmed/20195525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009409
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