Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS

Caloric restriction (CR) extends lifespan through a reduction in oxidative stress, delays the onset of morbidity and prolongs lifespan. We previously reported that long-term CR hastened clinical onset, disease progression and shortened lifespan, while transiently improving motor performance in G93A...

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Bibliographic Details
Main Authors: Patel, Barkha P., Safdar, Adeel, Raha, Sandeep, Tarnopolsky, Mark A., Hamadeh, Mazen J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827549/
https://ncbi.nlm.nih.gov/pubmed/20195368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009386
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