Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells

BACKGROUND: We previously reported that overexpression of Axin downregulates T cell factor-4 (TCF-4) transcription. However, the mechanism(s) by which Axin downregulates the transcription and expression of TCF-4 is not clear. It has been reported that β-catenin promotes and p53 inhibits TCF-4 transc...

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Главные авторы: Yang, Lian-He, Xu, Hong-Tao, Han, Yang, Li, Qing-Chang, Liu, Yang, Zhao, Yue, Yang, Zhi-Qiang, Dong, Qian-Ze, Miao, Yuan, Dai, Shun-Dong, Wang, En-Hua
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827467/
https://ncbi.nlm.nih.gov/pubmed/20122174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-25
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