Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1-patient exposed to efavirenz for three weeks: a case report and review of the literature

INTRODUCTION: Selection of the K103N mutation is associated with moderately reduced in vitro fitness of HIV. Strains bearing K103N in vivo tend to persist, even in the absence of additional drug pressure, as minority quasispecies, often undetectable in genotyping resistance testing assays, performed...

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Detalhes bibliográficos
Main Authors: Polilli, Ennio, Parruti, Giustino, Cosentino, Luana, Sozio, Federica, Saracino, Annalisa, Consorte, Augusta, Angarano, Gioacchino, Di Masi, Francesco, Mazzotta, Elena, Fazii, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Case report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827172/
https://ncbi.nlm.nih.gov/pubmed/21092074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4076/1752-1947-3-9132
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