cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

Treatment of intact human platelets with the adenylate cyclase agonist forskolin (100 microM) resulted in an increase in cAMP phosphodiesterase activity in freeze-thaw lysates. When the low-Km (high affinity), cGMP-inhibited cAMP phosphodiesterase was isolated from such lysates by blue dextran-Sepha...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Grant, P G, Mannarino, A F, Colman, R W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2461561/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.9071
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