EFFECT OF CALORIC RESTRICTION ON BASE EXCISION REPAIR (BER) IN THE AGING RAT BRAIN

Apyrimidinic/apurinic endonuclease (APE) is a key protein involved in the base excision DNA repair (BER) pathway of oxidative DNA lesions. Using a novel oligonucleotide substrate, we demonstrate that APE activity in the frontal/parietal cortex (F/PCTX), cerebellum, brainstem, midbrain and hypothalam...

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Hlavní autoři: Kisby, Glen E., Kohama, Steven G., Olivas, Antoinette, Churchwell, Mona, Doerge, Daniel, Spangler, Edward, de Cabo, Rafael, Ingram, Donald K., Imhof, Barry, Bao, Gaobin, Kow, Yoke W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826610/
https://ncbi.nlm.nih.gov/pubmed/20005284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2009.12.003
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