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Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer
Genome-wide association studies (GWAS) using population-based designs have identified many genetic loci associated with risk of a range of complex diseases including cancer; however, each locus exerts a very small effect and most heritability remains unexplained. Family-based pedigree studies have a...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826571/ https://ncbi.nlm.nih.gov/pubmed/20106545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2009.12.008 |
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