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Sex effects of Interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice

High levels of Interleukin-6 (IL-6) are associated with an increased risk of dementia in the elderly and can increase neuroinflammation in mice. Dementia is more frequent in females, and IL-6 is regulated by estrogen, suggesting elevated IL-6 levels may contribute to neuroinflammation and dementia p...

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Bibliografiska uppgifter
Huvudupphovsmän: Miller, VM, Lawrence, DA, Coccaro, GA, Mondal, TK, Andrews, K, Dreiem, A, Seegal, RF
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826563/
https://ncbi.nlm.nih.gov/pubmed/20060814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.12.091
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