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The strength of transcription-factor binding modulates co-variation in transcriptional networks

An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the...

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Detalhes bibliográficos
Main Authors: Nuzhdin, Sergey V., Rychkova, Anna, Hahn, Matthew W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826431/
https://ncbi.nlm.nih.gov/pubmed/20080313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2009.12.005
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