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Inhibition of H+-transporting ATPase by formation of a tight nucleoside diphosphate-fluoroaluminate complex at the catalytic site.

Inhibition of the mitochondrial and bacterial F1-type ATPases [of ATP phosphohydrolase (H+-transporting), EC 3.6.1.34] by fluoride was found to depend on the presence of aluminum and ADP at the catalytic site(s) of F1-type ATPase. AIF-4 was demonstrated to be the active fluoroaluminate species. The...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lunardi, J, Dupuis, A, Garin, J, Issartel, J P, Michel, L, Chabre, M, Vignais, P V
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282629/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2904148/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.8958
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