Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins

Novel strategies to control the binding of adhesion molecules belonging to the selectin family are required for the treatment of inflammatory diseases. We tested the possibility that synthetic monosaccharide analogs can compete with naturally occurring sugars to alter the O-glycan content on human l...

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Detalhes bibliográficos
Main Authors: Marathe, Dhananjay D., Buffone, Alexander, Chandrasekaran, E. V., Xue, Jun, Locke, Robert D., Nasirikenari, Mehrab, Lau, Joseph T. Y., Matta, Khushi L., Neelamegham, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826240/
https://ncbi.nlm.nih.gov/pubmed/19996411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231480
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